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Cetuximab-mediated Tumor Regression Depends on Innate and Adaptive Immune Responses

✍ Scribed by Yang, Xuanming; Zhang, Xunmin; Mortenson, Eric D; Radkevich-Brown, Olga; Wang, Yang; Fu, Yang-Xin

Book ID
118253794
Publisher
Nature Publishing Group
Year
2013
Tongue
English
Weight
651 KB
Volume
21
Category
Article
ISSN
1525-0016

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We have investigated the importance of endogenously produced IL-12 in innate and adaptive immunity to tumor transplants. The immunogenic lymphoma RMA and its TAP-deficient variant RMA-S were tested for rejection responses by normal and IL-12-deficient mice. IL-12 was crucial for the immunity induced