✦ LIBER ✦

Cetuximab as primary treatment for cutaneous squamous cell carcinoma to the neck

✍ Scribed by Sung Kim; Michael Eleff; Nicos Nicolaou

Publisher: John Wiley and Sons
Year: 2011
Tongue: English
Weight: 172 KB
Volume: 33
Category: Article
ISSN: 1043-3074
DOI: 10.1002/hed.21299

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✦ Synopsis

Abstract

Background.

Head and neck cutaneous squamous cell carcinoma (SCC) metastatic to lymph nodes is commonly treated with surgery plus radiotherapy.

Methods.

We present the case of a 92‐year‐old man with cutaneous SCC metastatic to the neck (7 cm) who was treated with primary cetuximab and has had a durable complete response for 7 months. Because of his age, comorbidities, and unresectable neck lymphadenopathy, he received primary cetuximab. He received a 400 mg/m^2^ loading dose and a 250 mg/m^2^ weekly dose for 3 months and then had to discontinue as a result of other unrelated medical issues.

Results.

The patient had a complete response by 6 weeks. Seven months after discontinuing cetuximab, he continues to have a complete response.

Conclusions.

Primary cetuximab for cutaneous SCC metastatic to lymph nodes is an area that bears further investigation because of its apparent efficacy and excellent toxicity profile. © 2009 Wiley Periodicals, Inc. Head Neck, 2011

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