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Cesium-133: A potential reporter of the hepatic uptake of contrast agents

✍ Scribed by Jean-Marie Colet; Sophie Lecomte; Luce Vander Elst; Robert N. Muller

Publisher
John Wiley and Sons
Year
2001
Tongue
English
Weight
146 KB
Volume
45
Category
Article
ISSN
0740-3194

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✦ Synopsis

Abstract

NMR spectroscopy of intracellularly located ^133^Cs has been used to monitor the uptake of Gd‐EOB‐DTPA by the isolated rat liver. As shown by ^31^P spectroscopy, accumulation of ^133^Cs ions in hepatocytes does not produce detectable effects on the metabolism. The hepatic internalization of Gd‐EOB‐DTPA was followed by the paramagnetic relaxation enhancement of the intracellular ^133^Cs ions, and confirmed by parallel quantitations of Gd and Cs run by inductively coupled plasma (ICP) analysis of liver samples and aliquots of perfusate. The relaxation data significantly underestimate the Gd content, suggesting a potential compartmentation of Cs^+^ and/or the contrast agent. Magn Reson Med 45:711–715, 2001. © 2001 Wiley‐Liss, Inc.

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