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Cervical ripening in humans: Potential roles of estrogen, progesterone, and insulin-like growth factor-I

✍ Scribed by Ylva Stjernholm; Lena Sahlin; Sonja Åkerbergb; Anna Elinder; Håkan A. Eriksson; Anders Malmström; Gunvor Ekman


Book ID
113983734
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
662 KB
Volume
174
Category
Article
ISSN
1097-6868

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The role of insulin-like growth factor-I (IGF-I) in regulating estrogen receptor-␣ (ER-␣) gene expression and activity was investigated in the human breast cancer cell line MCF-7. Treatment of cells with 40 ng/ml IGF-I resulted in a 60% decrease in ER-␣ protein concentration by 3 h, and the amount o