Cervical cancer, HPV 16 E6, variant genotypes, and serology
✍ Scribed by Ingo Nindl; Knuth Rindfleisch; Karin Teller; Achim Schneider; Matthias Dürst
- Book ID
- 117295516
- Publisher
- The Lancet
- Year
- 1999
- Tongue
- English
- Weight
- 44 KB
- Volume
- 353
- Category
- Article
- ISSN
- 0140-6736
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Sera from patients with cervical cancer, cervical intraepithelial neoplasia (CIN) and non-genital cancers, and from healthy individuals, were investigated for antibodies to human papilloma virus (HPV) early proteins E4, E6 and E7 and the major capsid protein LI by Western blot analysis of recombinan
## Abstract Infection with human papillomavirus type 16 (HPV16) confers a high risk for the development of cervical cancer. Variants of this virus may interact differentially with host genetic factors, possibly affecting the disease pathogenesis. This study was designed to investigate the associati
Human papillomaviruses (HPVs) are strongly associated with the development of high grade cervical intraepithelial neoplasia (CIN) and cervical carcinoma, with between 40-80% of patients with cervical carcinoma being attributed to a single HPV type, HPV16 depending on the methods used and geographica
High-risk human papillomaviruses (HPV), particularly HPV 16, are associated with invasive cervical cancer (ICC), and persistent high-risk HPV infection is considered to be a marker for progressive cervical intra-epithelial neoplasia (CIN). However, most high-risk, HPV-infected, pre-cancerous lesions