Cerium(III) chloride mediated regioselective synthesis of cyclic α-chloro-α,β-enones and α-chloro-β-hydroxy ketones

✍ Scribed by Antonio Garrido Montalban; Lars-Oliver Wittenberg; Alexander McKillop

• Book ID: 104261912
• Publisher: Elsevier Science
• Year: 1999
• Tongue: French
• Weight: 196 KB
• Volume: 40
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(99)01129-6

✦ Synopsis

Reaction of cyclic ~,l~-epoxy ketones with Ce(III) chloride under hydrous or anhydrous conditions yields the corresponding cyclic 0t-chloro-0t,13-enones or cyclic ~-chloro-~-hydroxy ketones, respectively.