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Cerium (IV) ammonium nitrate as an efficient Lewis acid for the one-pot synthesis of 3,4-dihydropyrimidin-2(1H)-ones and their corresponding 2-(1H) thiones

✍ Scribed by Kamal Usef Sadek; Fawzia Al-Qalaf; Mervat Mohammed Abdelkhalik; Mohamed Hilmy Elnagdi

Publisher
Journal of Heterocyclic Chemistry
Year
2010
Tongue
English
Weight
67 KB
Volume
47
Category
Article
ISSN
0022-152X

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✦ Synopsis

Abstract

magnified image
A simple and highly efficient procedure for the Biginelli condensation reaction of aldehydes, β‐ketoesters, urea, or thiourea catalyzed by Ceric ammonium nitrate (CAN) as a Lewis‐acid at ambient temperature is described. The procedure proved to be simple and of high yield. J. Heterocyclic Chem., (2010).

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## Abstract magnified image 3,4‐Dihydropyrimidin‐2‐(1__H__)‐ones and their thione analogues are synthesized from the condensation of aromatic aldehydes, β‐dicarbonyl compound and urea or thiourea in presence of 5 mol% of oxalic acid in ethanol‐water (1:2; v/v) under mild reaction conditions. The y