𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Cerebrospinal fluid neurofilament and glial fibrillary acidic protein in patients with cerebral vasculitis

✍ Scribed by K. Nylén; J-E. Karlsson; C. Blomstrand; A. Tarkowski; E. Trysberg; L.E. Rosengren

Publisher
John Wiley and Sons
Year
2002
Tongue
English
Weight
92 KB
Volume
67
Category
Article
ISSN
0360-4012

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Few diseases in clinical medicine cause as much diagnostic consternation as central nervous system (CNS) vasculitis because of its varying modes of presentation and frequently overlapping clinical and pathological features. There are no pathognomonic clinical or laboratory findings. The purpose of the present retrospective study was to validate the use of the light subunit of neurofilament triplet protein (NFL) and glial fibrillary acidic protein (GFAP) as markers of CNS tissue damage for patients with systemic or isolated CNS vasculitis. Levels of cerebrospinal fluid (CSF) NFL and GFAP were measured using ELISAs. Both CSF NFL and CSF GFAP concentrations were significantly higher in a patient group diagnosed with CNS vasculitis (P < 0.01 and P < 0.05, respectively) than in a patient group for whom CNS vasculitis was excluded. In the future, analysis of CSF NFL in particular, but also GFAP, may be a useful complement in the difficult clinical task of diagnosing CNS vasculitis. © 2002 Wiley‐Liss, Inc.

📜 SIMILAR VOLUMES

Plasma glial fibrillary acidic protein l
Plasma glial fibrillary acidic protein levels in children with sickle cell disease
✍ William J. Savage; Emily Barron-Casella; Zongming Fu; Pratima Dulloor; Lisa Will 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 English ⚖ 243 KB 👁 2 views

To determine if glial fibrillary acidic protein (GFAP) is associated with brain injury in children with sickle cell disease (SCD), we measured plasma GFAP among cross-sectional groups of unselected children with SCD, subsets of children with SCD and normal brain MRI or MRI evidence of cerebral infar

Basic fibroblast growth factor, neurofil
Basic fibroblast growth factor, neurofilament, and glial fibrillary acidic protein immunoreactivities in the myenteric plexus of the rat esophagus and colon
✍ Gerson Chadi; Vânia Canterucci Gomide; Romeu Rodrigues de Souza; Rodrigo Torres 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 English ⚖ 703 KB

## Abstract The enteric nervous system consists of a number of interconnected networks of neuronal cell bodies and fibers as well as satellite cells, the enteric glia. Basic fibroblast growth factor (bFGF) is a mitogen for a variety of mesodermal and neuroectodermal‐derived cells and its presence h

Specific alteration in the expression of
Specific alteration in the expression of glial fibrillary acidic protein, glutamate dehydrogenase, and glutamine synthetase in rats with genetic absence epilepsy
✍ Magali Dutuit; Marianne Didier-Bazès; Marguerite Vergnes; Mireille Mutin; Agnès 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 470 KB 👁 3 views

Astrocytes play a predominant role in energy metabolism and in the catabolism of gamma-aminobutyric acid (GABA) and glutamate, neurotransmitters critically involved in epileptic processes. We show specific astrocytic alterations in the genetic absence epilepsy rats from Strasbourg (GAERS). Spontaneo

Dominantly-inherited adult-onset leukody
Dominantly-inherited adult-onset leukodystrophy with palatal tremor caused by a mutation in the glial fibrillary acidic protein gene
✍ Dominic Thyagarajan; Timothy Chataway; Rong Li; Wei Ping Gai; Michael Brenner 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 English ⚖ 530 KB

## Abstract We report on a pedigree of dominantly‐inherited, adult‐onset Alexander disease caused by the glial fibrillary acidic protein (GFAP) gene mutation, R416W. This pedigree highlights the importance of genetic analysis of the GFAP gene in leukodystrophy with palatal tremor. © 2004 Movement D