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Cerebrospinal fluid lipids in demyelinating disease

โœ Scribed by D. Seidel; R. Buck; R. Heipertz; H. Pilz

Book ID
104717577
Publisher
Springer
Year
1980
Tongue
English
Weight
306 KB
Volume
222
Category
Article
ISSN
0340-5354

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โœฆ Synopsis

The lipid composition of CSF, serum and lymphocytes from patients without demyelinating disease (controls) as well as from patients with acute and chronic MS is analyzed. Individual lipid fractions are isolated by TLC and their fatty acid composition determined. Lipid and fatty acid composition of normal CSF resembles the results found in lymphocytes and it is deduced that CSF lipids are derived mainly from lymphocytes rather than white matter (myelin) or serum. There is an increase of CSF sphingomyelin in patients with acute MS (showing pleocytosis) which is apparently derived from disintegrated lymphocytes; there is also an increase of linoleic acid concentration which could come from serum because of dysfunction of the blood-brain barrier. The role of the CNS in contributing to CSF lipids is considered negligible both in controls and in patients with demyelination.

๐Ÿ“œ SIMILAR VOLUMES

Cerebrospinal fluid lipids in demyelinat
Cerebrospinal fluid lipids in demyelinating disease
โœ D. Seidel; R. Heipertz; B. Weisner ๐Ÿ“‚ Article ๐Ÿ“… 1980 ๐Ÿ› Springer ๐ŸŒ English โš– 271 KB

The absolute linoleic acid concentration in CSF was determined and the findings of MS patients (n = 10) and controls (n = 12) were compared. The linoleic acid content of control CSF (1.6 +/- 0.8 nMol/ml) is considerably lower than the corresponding serum value (2.5--4.1 muMol/ml). Although CSF from