Cerebrospinal fluid levels of quinolinic acid in Huntington's disease and schizophrenia

✍ Scribed by Dr. Robert Schwarcz; Carol A. Tamminga; Roger Kurlan; Ira Shoulson

• Publisher: John Wiley and Sons
• Year: 1988
• Tongue: English
• Weight: 292 KB
• Volume: 24
• Category: Article
• ISSN: 0364-5134
• DOI: 10.1002/ana.410240417

✦ Synopsis

be related to a lysosomal storage disorder. However, they were unable to identify a specific lysosomal enzyme abnormality.

In summary, we have described the pathological features of muscle biopsy specimens from 3 infantile cases of Marinesco-S jogren syndrome. W e have identified an unusual ultrastructural feature that we believe is specific for the syndrome. This emphasizes the role of muscle biopsy in the differential diagnosis of MSS and highlights the involvement of skeletal muscle in the disorder.

We are grateful to the Muscular Dystrophy Group of Great Britain and Northern Ireland for financial support and to Mrs C. A. Lovegrove and Mrs C. Hutson for technical expertise. We also thank Mrs C. Trand for typing the manuscript. Dr Voit is the recipient of a postdoctoral grant from the Deutsche Forschungsgemeinschaft,