CEREBROSPINAL FLUID CONCENTRATIONS OF CYTOSINE ARABINOSIDE DURING INTRAVENOUS THERAPY WITH INTERMEDIATE DOSE: A PRELIMINARY REPORT

The pharmacokinetics of cytosine arabino

The pharmacokinetics of cytosine arabinoside in the plasma and cerebrospinal fluid during conventional and high-dose therapy

✍ Slevin, M. L. ;Piall, E. M. ;Aherne, G. W. ;Johnston, A. ;Lister, T. A. 📂 Article 📅 1982 🏛 John Wiley and Sons 🌐 English ⚖ 638 KB

Subcutaneous bolus administration of cytosine arabinoside (Ara-C) has been used as an alternative to continuous intravenous infusion. However, the pharmacokinetics of subcutaneous bolus Ara-C have not been satisfactorily documented in man. The plasma concentrations of Ara-C were therefore compared f