Cerebrospinal fluid Aβ42 is increased early in sporadic Alzheimer's disease and declines with disease progression
✍ Scribed by Malene Jensen; Johannes Schröder; Mari Blomberg; Benita Engvall; Johannes Pantel; Nobuo Ida; Hans Basun; Lars-Olof Wahlund; Egon Werle; Marek Jauss; Konrad Beyreuther; Lars Lannfelt; Tobias Hartmann
- Publisher
- John Wiley and Sons
- Year
- 1999
- Tongue
- English
- Weight
- 234 KB
- Volume
- 45
- Category
- Article
- ISSN
- 0364-5134
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## Abstract The amyloid β‐protein is a 39‐42 amino acid peptide that is deposited in senile plaques and in cerebral vessel walls in individuals with Alzheimer's disease, Down's syndrome, hereditary cerebral hemorrhage with amyloidosis–Dutch type (HCHW A‐D), and, to a much lesser extent, normal agin
Objective: To identify cognitively normal individuals at risk of Alzheimer disease (AD) based on cerebrospinal fluid (CSF) Ab1-42, and to determine rates of cerebral atrophy. Methods: Control subjects from the Alzheimer's Disease Neuroimaging Initiative with CSF and serial magnetic resonance imaging