Cerebral venous thrombosis in inflammatory bowel diseases

✍ Scribed by Sébastien Richard; Aurélia Fairise; Jean-Christophe Lacour; Xavier Ducrocq

• Publisher: John Wiley and Sons
• Year: 2010
• Tongue: English
• Weight: 49 KB
• Volume: 16
• Category: Article
• ISSN: 1078-0998
• DOI: 10.1002/ibd.20996

✦ Synopsis

Thromboembolic disease is a rare but serious complication of inflammatory bowel diseases (IBD) such as Crohn's disease (CD) and ulcerative colitis (UC). Talbot et al 1 found only 1.3% of thromboembolic complications in a population of 7199 patients with IBD during an 11-year period. Prognosis is poor, with 25% mortality among IBD patients with thromboembolic complications. However, there is little mention in the literature of cerebral venous thrombosis (CVT) concurrently developed with IBD. A prospective international study on cerebral vein and dural sinus thrombosis 2 found that only 1.6% of CVT is associated with IBD and that the outcome is poor. We take into consideration this complication, discussing the prognosis, physiopathology, and treatment.

Data from IBD patients who developed CVT between 2000 and 2005 at the Department of Neurology at the Hospital of Nancy were retrospectively collected. History, clinical course, intestinal histology, involvement of cerebral veins, localization of thrombosis, ischemic, hemorrhagic cerebral complications, therapy, laboratory data (platelet, prothrombin time, activated partial thromboplastin time, antithrombin, protein C, protein S, activated protein C resistance, and anticardiolipin antibody), and outcome were reviewed.