Cerebral vascular response to hypercapnia: Determination with perfusion MRI at 1.5 and 3.0 Tesla using a pulsed arterial spin labeling technique
✍ Scribed by Ulrike Nöth; Guy E. Meadows; Futoshi Kotajima; Ralf Deichmann; Douglas R. Corfield; Robert Turner
- Publisher
- John Wiley and Sons
- Year
- 2006
- Tongue
- English
- Weight
- 479 KB
- Volume
- 24
- Category
- Article
- ISSN
- 1053-1807
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✦ Synopsis
Abstract
Purpose
To compare the quantification of cerebral blood flow (CBF) at 1.5 and 3.0 Tesla, under normo‐ and hypercapnia, and to determine the cerebral vascular response (CVR) of gray matter (GM) to hypercapnia, a pulsed arterial spin labeling technique was used. Additionally, to improve GM CBF quantification a high‐resolution GM‐mask was applied.
Materials and Methods
CBF was determined with the QUIPSS II with thin slice TI1 periodic saturation (Q2TIPS) sequence at 1.5 and 3.0 Tesla in the same group of eight subjects, both under normocapnia and hypercapnia. Absolute GM‐CBF maps were calculated using a GM‐mask obtained from a high‐resolution structural scan by segmentation. The CVR to hypercapnia was derived from the quantitative GM‐CBF maps.
Results
For both field strengths, the GM‐CBF was significantly higher under hypercapnia compared to normocapnia. For both conditions, there was no significant difference of GM‐CBF for 1.5 and 3.0 Tesla; the same applies to the CVR, which was 4.3 and 4.5%/mmHg at 1.5 and 3.0 Tesla, respectively.
Conclusion
The method presented allows for the quantification of CBF and CVR in GM at the common clinical field strengths of 1.5 and 3.0 Tesla and could therefore be a useful tool to study these parameters under physiological and pathophysiological conditions. J. Magn. Reson. Imaging 2006. © 2006 Wiley‐Liss, Inc.