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Cerebral glucose and glycogen metabolism in diazinon-treated animals

✍ Scribed by Matin, M. A. ;Husain, K.

Publisher
John Wiley and Sons
Year
1987
Tongue
English
Weight
304 KB
Volume
2
Category
Article
ISSN
0887-2082

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✦ Synopsis

The intraperitoneal (IP) treatment of rats with diazinon (40 mg/kg) resulted in a variety of changes in the brain. Glycogen was depleted, but there was an increase in the activities of glycogen phosphorylase, phosphoglucomutase, hexokinase, lactate dehydrogenase, and fructose 1,6 diphosphatase. The activity of glucose-6-phosphatase was unaffected while that of cholinesterase was significantly reduced. Lactic acid content was increased, while that of pyruvate was not altered. Animals developed tremors and convulsions, which were maximal two hours after treatment. The induced changes may be compensatory mechanisms to provide extra energy to cerebral tissue as a result of the stimulatory effects in diazinon-treated animals.

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