## Abstract Hepatic encephalopathy (HE) in both acute and chronic liver failure is more likely a reversible functional disease rather than an irreversible pathological lesion of brain cells. Metabolic alterations underlie many of the mechanisms leading to HE. This paper summarizes in vivo and ex vi
β¦ LIBER β¦
Cerebral Energy Metabolism in Hepatic Encephalopathy and Hyperammonemia
β Scribed by K.V. Rama Rao; M.D. Norenberg
- Book ID
- 110304175
- Publisher
- Springer
- Year
- 2001
- Tongue
- English
- Weight
- 59 KB
- Volume
- 16
- Category
- Article
- ISSN
- 0885-7490
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Abnormalities in glutamate metabolism and glutamatergic neurotransmission appear to play a major role in the pathogenesis of hyperammonemia and hepatic encephalopathy. Astrocytes may be involved in these derangements as ammonia has been shown to impair the ability of these cells to take up glutamate
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