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Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) and a family with a new Notch3 mutation

✍ Scribed by M. Ascension Zea-Sevilla; Elena Toribio-Diaz; Samer Al-Hussayni; Fernando Perez -Parra; Pedro Bermejo-Velasco

Book ID: 118467434
Publisher: Elsevier Science
Year: 2011
Tongue: English
Weight: 49 KB
Volume: 7
Category: Article
ISSN: 1552-5260
DOI: 10.1016/j.jalz.2011.05.570

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Vascular dementia is usually sporadic and associated with definite risk factors. Several cases also occur in a familial fashion, and may affect middle-aged or even younger subjects. Recently, an autosomal dominant inheritance was demonstrated in two unrelated French families, the members of which we