Cerebellar modules: Molecules, morphology and function

✍ Scribed by N.M. Gerrits, T.J.H. Ruigrok, C.I. de Zeeuw (Eds.)

• Publisher: Elsevier, Academic Press
• Year: 2000
• Tongue: English
• Series: Progress in Brain Research 124
• Edition: 1st
• Category: Library

✦ Synopsis

The present volume of Progress in Brain Research contains the proceedings of a Symposium entitled Cerebellar Modules: Molecules, Morphology and Function, which was held to mark the retirement of Jan Voogd as chairman of the Department of Anatomy at the Erasmus University of Rotterdam. The contributions of leading cerebellar scientists representing a variety of disciplines focussed around the issue of the cerebellar modular compartmentalization, the intriguing composition of which has for many decades been the driving force behind Voogd's extraordinarily detailed anatomical analyses. The first section of the book, Development, concentrates on the genetic basis of different aspects of compartmentalized development including a most important contribution on the postnatal development of the climbing fiber system. Gene expression is also an important element in the next section, Interneurons, which provides striking new data and hypotheses on the functional anatomy of granule cells, Golgi cells and unipolar brush cells. Particularly interesting are several contributions that offer a novel view on parallel fiber function. The section Modules and Circuits provides a number of state-of-the-art analyses using electrophysiological, and classical and transneuronal virus tracing techniques. The emphasis lies on the olivocerebellar circuits and the oculomotor system The final section, Models and Learning, offers an insight into the progress on the mechanisms and network organization of adaptation and learning, not only in classical paradigms like oculomotor and eye blink responses but also in studies linking gene expression to behavioral paradigms The editors are confident that the exciting data and concepts collected in this volume will strengthen the multidisciplinary approach in the field of cerebellar research.

✦ Table of Contents

Content:
List of contributors
Pages v-viii

List of participants
Pages ix-xi

Preface
Pages xiii-xiv
N.M. Gerrits

Acknowledgements
Page xv
N.M. Gerrits, T.J.H. Ruigrok, C.I. De Zeeuw

Neuroepithelial ‘compartments’ and the specification of vestibular projections Original Research Article
Pages 3-21
Joel C. Glover

Antero-posterior boundaries and compartments in the cerebellum: evidence from selected neurological mutants Original Research Article
Pages 23-30
Leonard M. Eisenman

Climbing fiber synapse elimination during postnatal cerebellar development requires signal transduction involving Gαq and phospholipase Cβ4 Original Research Article
Pages 31-48
K. Hashimoto, M. Watanabe, H. Kurihara, S. Offermanns, H. Jiang, Y. Wu, K. Jun, H.-S. Shin, Y. Inoue, D. Wu, M.I. Simon, M. Kano

Lineage, development and morphogenesis of cerebellar interneurons Original Research Article
Pages 51-68
Karl Schilling

Transgenic methods for directing gene expression to specific neuronal types: cerebellar granule cells Original Research Article
Pages 69-80
A Jones, M Paterlini, W Wisden, D Merlo

The function of cerebellar Golgi cells revisited Original Research Article
Pages 81-93
Erik De Schutter, Bart Vos, Reinoud Maex

Precise spike timing of tactile-evoked cerebellar golgi cell responses: a reflection of combined mossy fiber and parallel fiber activation? Original Research Article
Pages 95-106
Bart P. Vos, Antonia Volny-Luraghi, Reinoud Maex, Erik De Schutter

Unravelling cerebellar circuitry: an optical imaging study Original Research Article
Pages 107-114
Dana Cohen, Yosef Yarom

Electrotonic coupling synchronizes interneuron activity in the cerebellar cortex Original Research Article
Pages 115-122
Puah Mann-Metzerand, Yosef Yarom

Unipolar brush cells of the vestibulocerebellum: afferents and targets Original Research Article
Pages 123-137
Maria R. Diño, Maria Grazia Nunzi, Roberta Anelli, Enrico Mugnaini

Topography of cerebellar nuclear projections to the brain stem in the rat Original Research Article
Pages 141-172
T.M. Teune, J. van der Burg, J. van der Moer, J. Voogd, T.J.H. Ruigrok

The entire trajectory of single climbing and mossy fibers in the cerebellar nuclei and cortex Original Research Article
Pages 173-186
Y. Shinoda, I. Sugihara, H.-S. Wu, Y. Sugiuchi

Micro-organisation of cerebellar modules controlling forelimb movements Original Research Article
Pages 187-199
Martin Garwicz

Gating of climbing fibre input to cerebellar cortical zones Original Research Article
Pages 201-211
Richard Apps

GABAergic modulation of olivary oscillations Original Research Article
Pages 213-220
Anna Devor, Yosef Yarom

Analysis of the discharge pattern of floccular Purkinje cells in relation to vertical head and eye movement in the squirrel monkey Original Research Article
Pages 221-232
Y. Hirata, S.M. Highstein

Hypotheses about the neural trigger for plasticity in the circuit for the vestibulo-ocular reflex Original Research Article
Pages 235-246
Jennifer L. Raymond, Stephen G. Lisberger

On the nature of gain changes of the optokinetic reflex Original Research Article
Pages 247-255
M.A. Frens, A.L. Mathoera, J. Van der Steen

Use-dependent changes in synaptic strength at the Purkinje cell to deep nuclear synapse Original Research Article
Pages 257-273
Carlos Daizenman, Eric J. Huang, Paul B. Manis, David J. Linden

Time window control: a model for cerebellar function based on synchronization, reverberation, and time slicing Original Research Article
Pages 275-297
Werner M. Kistler, J.Leo van Hemmen, Chris I. De Zeeuw

Electrophysiological behavior of Purkinje cells and motor coordination in calretinin knock-out mice Original Research Article
Pages 299-308
Guy Cheron, Stéphane Schurmans, Ann Lohof, Pablo d'Alcantara, Michael Meyer, Jean-Philippe Draye, Marc Parmentier, Serge N. Schiffmann

Contralateral cerebellar involveent in conditioned eyeblink responses Original Research Article
Pages 309-316
M. Ivarsson, P. Svensson, G. Hesslow

Involvement of the cerebellum in a new temporal property of the conditioned eyeblink response Original Research Article
Pages 317-323
Pär Svensson, Magnus Ivarsson, Germund Hesslow

Subject index
Pages 325-330