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Cerebellar degeneration and polyglandular autoimmune syndrome with anti-glutamic acid decarboxylase antibodies

✍ Scribed by S. Rüegg; M. Stahl; M. Bühlmann; A. Dupont; P. A. Lyrer; R. L. Humbel; A. J. Steck

Publisher
Springer
Year
2002
Tongue
English
Weight
108 KB
Volume
249
Category
Article
ISSN
0340-5354

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Glutamic acid decarboxylase (GAD) is an enzyme that catalyzes the conversion of glutamate to ␥-aminobutyric acid (GABA). Anti-GAD antibody (GAD-Ab) is considered to be a marker for stiff person syndrome (SPS), 1 insulin-dependent diabetes mellitus (IDDM), and polyendocrine autoimmune syndrome. 2 Add