Ceramides and Cerebrosides from Ligusticum chuanxiongHort.

✍ Scribed by Nian-Yun Yang; Dong-Chun Ren; Jin-Ao Duan; Xiao-Hua Xu; Ning Xie; Li-Juan Tian

• Book ID: 102256833
• Publisher: John Wiley and Sons
• Year: 2009
• Tongue: German
• Weight: 183 KB
• Volume: 92
• Category: Article
• ISSN: 0018-019X
• DOI: 10.1002/hlca.200800240

✦ Synopsis

Abstract

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Two new ceramides, (2__R__)‐2‐hydroxy‐N‐[(2__S__,3__S__,4__R__,8__E__)‐1,3,4‐trihydroxypentadec‐8‐en‐2‐yl]heptacosanamide (1) and (2__R__)‐2‐hydroxy‐N‐{(3__S__,4__S__,5__S__)‐4‐hydroxy‐5‐[(4__E__)‐undec‐4‐en‐1‐yl]tetrahydrofuran‐3‐yl}heptacosanamide (2), were isolated from the aerial parts of Ligusticum chuanxiong, along with one known ceramide, (2__R__)‐2‐hydroxy‐N‐[(2__S__,3__S__,4__R__,8__E__)‐1,3,4‐trihydroxyicos‐8‐en‐2‐yl]tetracosanamide (3), and two known cerebrosides, (2__R__)‐N‐[(2__S__,3__R__,4__E__,8__E__)‐1‐(β‐D‐glucopyranosyloxy)‐3‐hydroxydodeca‐4,8‐dien‐2‐yl]‐2‐hydroxydocosanamide (4) and (2__R__)‐N‐[(2__S__,3__S__,4__R__,8__E__)‐1‐(β‐D‐glucopyranosyloxy)‐3,4‐dihydroxyoctadec‐8‐en‐2‐yl]‐2‐hydroxyhexadecanamide (5). Their structures were elucidated by extensive spectroscopic analysis, including 1D‐ and 2D‐NMR, as well as HR‐ESI‐MS experiments.