Ceramide metabolism in brain
โ Scribed by Yasuo Kishimoto; Nariko Kawamura
- Book ID
- 104672283
- Publisher
- Springer
- Year
- 1979
- Tongue
- English
- Weight
- 676 KB
- Volume
- 23
- Category
- Article
- ISSN
- 0300-8177
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โฆ Synopsis
Ceramide is the fundamental structure and key intermediate of all sphingolipids. Biosynthesis and catabolism of brain ceramide, especially their relationship to the metabolism of more complex sphingolipids in brain, are reviewed. Human genetic diseases which involve altered ceramide metabolism are also discussed.
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## Abstract Tumor cell resistance to chemotherapy constitutes a major problem in the treatment of malignant tumors. We here investigated the role of ceramide metabolism for the resistance of glioma cells to treatment with the chemotherapeutic drug, gemcitabine. Gemcitabine triggers a marked release