Ceramide in primary astrocytes from cerebellum: metabolism and role in cell proliferation
โ Scribed by Laura Riboni; Guido Tettamanti; Paola Viani
- Book ID
- 111740967
- Publisher
- Springer-Verlag
- Year
- 2002
- Tongue
- English
- Weight
- 303 KB
- Volume
- 1
- Category
- Article
- ISSN
- 1473-4222
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๐ SIMILAR VOLUMES
To evaluate the role of ceramide in glial growth, primary cultures of quiescent astrocytes from rat cerebellum were stimulated to proliferate by mitogenic doses of basic fibroblast growth factor (bFGF). Parallel to the bFGF mitogenic effect was a marked, and persistent, decrease in cellular ceramide
Evidence suggests that astrocytes might play an important role in cerebral energy metabolism. A recently developed cell line, called DI TNC 1 , displays several characteristic features of astrocytes. Thus, we have investigated in these cells a number of parameters related to energy metabolism. First