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Ceramide Analogues in Apoptosis: A New Strategy for Anticancer Drug Development

✍ Scribed by Marco Macchia; Simone Bertini; Stefano Fogli; Elisa Giovannetti; Filippo Minutolo; Simona Rapposelli; Romano Danesi

Publisher
John Wiley and Sons
Year
2003
Weight
57 KB
Volume
34
Category
Article
ISSN
0931-7597

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✍ Roshini Rajan; Kurt Wallimann; Andrea Vasella; Deborah Pace; Armando A. Genazzan 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 English ⚖ 333 KB

## Abstract The 7‐oxasphingosine (**1**), 7‐oxaceramide (**2**), the thio‐oxaceramide **3**, and __N__‐methyloxaceramide **4** were synthesised from D‐galactose __via__ the building block **9**. The apoptosis‐inducing properties of **1**–**4** were compared to those of sphingosine (Sph) and ceramid