✦ LIBER ✦

Centrosome function in normal and tumor cells

✍ Scribed by Satish Sankaran; Jeffrey D. Parvin

Publisher: John Wiley and Sons
Year: 2006
Tongue: English
Weight: 213 KB
Volume: 99
Category: Article
ISSN: 0730-2312
DOI: 10.1002/jcb.21003

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✦ Synopsis

Abstract

Centrosomes nucleate microtubules that form the mitotic spindle and regulate the equal division of chromosomes during cell division. In cancer, centrosomes are often found amplified to greater than two per cell, and these tumor cells frequently have aneuploid genomes. In this review, we will discuss the cellular factors that regulate the proper duplication of the centrosome and how these regulatory steps can lead to abnormal centrosome numbers and abnormal mitoses. In particular, we highlight the newly emerging role of the Breast Cancer 1 (BRCA1) ubiquitin ligase in this process. J. Cell. Biochem. 99: 1240–1250, 2006. © 2006 Wiley‐Liss, Inc.

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