Increase in gene dosage is a mechanism o
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Pablo Secades; Juan Pablo Rodrigo; Mario Hermsen; Cesar Alvarez; Carlos Suarez;
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Article
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2009
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John Wiley and Sons
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English
⚖ 461 KB
## Abstract The HIF‐1α protein plays a key role in the cellular response to hypoxia via transcriptional regulation of genes involved in erythropoiesis, angiogenesis, and metabolism. Overexpression of HIF‐1α is commonly found in solid tumors in significant association with increased patient mortalit