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Centrilobular necrosis after orthotopic liver transplantation: A longitudinal clinicopathologic study in 71 patients

✍ Scribed by Turlin, Bruno ;Slapak, Gabriella I. ;Hayllar, Karen M. ;Heaton, Nigel ;Williams, Roger ;Portmann, Bernard

Book ID: 102933705
Publisher: Wiley (John Wiley & Sons)
Year: 1995
Tongue: English
Weight: 873 KB
Volume: 1
Category: Article
ISSN: 1074-3022
DOI: 10.1002/lt.500010503

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✦ Synopsis

Centrilobular necrosis (CLN) is a histological finding often encountered after orthotopic liver transplantation, but its pathogenesis is still unknown. In this study, the significance of CLN was assessed in a series of 227 consecutive liver transplantations performed between January 1989, and December 1991. Seventy-one patients (30.9%) showed CLN on at least one biopsy result, which were obtained because of an increase of aspartate aminotransferase activity. Their liver specimens were reviewed, and 19 histological features were recorded with particular attention given to lobular changes in acinar zone 3, to features commonly attributed to cellular and ductopenic rejection, and to changes suggestive of ischemia. CLN could first be observed either soon (within 4 days) or late (up to 3 years) after transplantation. Only 23 (32.4%) specimens had centrilobular necrosis affecting more than 75% of acinar zones 3. fter orthotopic liver transplantation (OLT), Lud-A wig et all have highlighted a histological lesion characterized by cell loss in acinar zone 3, which they named centrilobular necrosis (CLN). The occurence of CLN after OLT had been mentioned in earlier W O ~~S ~. ~

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