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Centric fission of chromosome No. 4 in the mother of two patients with trisomy 4p

✍ Scribed by Bruno Dallapiccola; Pierpaolo Mastroiacovo; Enrico Gandini

Publisher: Springer
Year: 1976
Tongue: English
Weight: 323 KB
Volume: 31
Category: Article
ISSN: 0340-6717
DOI: 10.1007/bf00270409

No coin nor oath required. For personal study only.

✦ Synopsis

Centric fission of chromosome No. 4 was found in the healthy mother of two children with trisomy 4p. The two telocentrics derived are stable and show no evidence of fusing again. The 2:3 ratio of unbalanced offsprings born to the proposita indicates that, contrary to the evidence emerging from studies in other species, the risk for the production of unbalanced gametes is high.

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