Central venous catheter infection byAspergillus fumigatus in a patient with B-type non-Hodgkin lymphoma

✍ Scribed by Berner, Reinhard; Sauter, Siegfried; Michalski, Yvonne; Niemeyer, Charlotte M.

• Publisher: John Wiley and Sons
• Year: 1996
• Tongue: English
• Weight: 543 KB
• Volume: 27
• Category: Article
• ISSN: 0098-1532
• DOI: 10.1002/(sici)1096-911x(199609)27:3<202::aid-mpo13>3.0.co;2-h

✦ Synopsis

lnvasive Aspergillus infection is still a major problem in imrnunocompromised patients. A central venous catheter infection by Aspergillus fumigatus, however, has not yet been reported. We describe the case of a 10-year-old female patient with B-type non-Hodgkin lymphoma treated according to the German chemotherapy protocol NHL-BFM 90. Isolation of Aspergillus fuumigatus from the blood was the first hint of invasive aspergillosis. A central venous catheter-associated infection was suggested, since Aspergillus was also isolated from the thrombotic tip of the removed catheter. Secondary pulmonary aspergillosis was documented radiologically. The patient was treated successfully by Amphothericin B and ltraconazol and explantation of the central venous catheter under conditions of complete hematopoietic regeneration of the bone marrow with omission of the final chemotherapeutic cycle.