Central precocious puberty and growth hormone deficiency in a boy with Prader-Willi syndrome
✍ Scribed by Antonino Crinò; Girolamo Di Giorgio; Riccardo Schiaffini; Alessandra Fierabracci; Sabrina Spera; Andrea Maggioni; Guido Castelli Gattinara
- Publisher
- Springer
- Year
- 2008
- Tongue
- English
- Weight
- 88 KB
- Volume
- 167
- Category
- Article
- ISSN
- 0340-6997
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## Abstract Growth hormone (GH) therapy for short stature in patients with Prader–Willi syndrome (PWS) has started worldwide, and various favorable effects have been reported. However, the possibility of progression of scoliosis arises as a new problem of the GH therapy. In this study, we analyzed
W e describe a boy who developed precocious puberty resulting from chorionic gonadotropin produced by a mediastinal germ cell tumor. Following tumor removal he began spontaneous precocious sexual development which was treated and then arrested spontaneously. Investigation of this arrested puberty es
## Abstract It has been suggested that reduced GH secretion in Prader–Willi syndrome (PWS) may simply reflect their excessive fat body mass. However, the GH response to standard provocative tests is significantly lower in PWS adults than obese controls with similar body mass index (BMI). Neverthele