Central nervous system depressant effect of Hoslundia opposita Vahl

✍ Scribed by Dr. O. A. Olajide; S. O. Awe; J. M. Makinde

• Publisher: John Wiley and Sons
• Year: 1999
• Tongue: English
• Weight: 29 KB
• Volume: 13
• Category: Article
• ISSN: 0951-418X
• DOI: 10.1002/(sici)1099-1573(199908/09)13:5<425::aid-ptr466>3.0.co;2-1

✦ Synopsis

The chloroform extract of the dried root of Hoslundia opposita has been evaluated for effects on the central nervous system (CNS). The extract significantly potentiated the phenobarbitone sleeping time in mice and produced a 60% protection against leptazol-induced convulsion. Neuropharmacological screening revealed CNS depression.