Central inflammation versus peripheral regulation in multiple sclerosis
β Scribed by L. J. Edwards; B. Sharrack; A. Ismail; H. Tumani; C. S. Constantinescu
- Publisher
- Springer
- Year
- 2011
- Tongue
- English
- Weight
- 426 KB
- Volume
- 258
- Category
- Article
- ISSN
- 0340-5354
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## Abstract The functional implications of central motor impairment and peripheral muscle alterations in multiple sclerosis are unclear. Muscle strength, central and peripheral activation, and symptomatic fatigue were investigated in 16 patients with multiple sclerosis (MS) and 18 control subjects.
The effect of baclofen on the soleus stretch reflex and peripheral muscle function was tested in 10 multiple sclerosis (MS) patients with spasticity in the lower extremities. Peroral baclofen (15-60 mg daily) induced a decrease in the twitch torque of the soleus muscle elicited by supramaximal nerve