Central depressant action of cesium in mice

✍ Scribed by Ranjan Bose; Carl Pinsky

• Book ID: 104771609
• Publisher: Springer
• Year: 1984
• Tongue: English
• Weight: 487 KB
• Volume: 84
• Category: Article
• ISSN: 0033-3158
• DOI: 10.1007/bf00432030

✦ Synopsis

Cesium chloride (CsC1) at several dose levels (1.25-20.0 mEq/kg IP) was administered acutely to albino mice whose behavior was compared with that in corresponding saline controls. Motor activity decreased and Straub tail occurred in a dose-related manner. Signs of autonomic disturbance, diarrhea, and salivation were seen with toxic doses. Subchronic administration of CsC1 (5.0 mEq/kg/day IP for 7 days) exerted a phenothiazine-like effect in mice, reducing amphetamine-induced aggregation toxicity and enhancing pentobarbital-induced hypnosis. The antinociceptive action of morphine was unaltered by identical multiple administrations of CsC1. These results indicate a specific neurosuppressant action of CsC1 on mouse CNS and suggest exploration of this alkali earth metal for antipsychotic-like activity.