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Central control of bone remodeling by neuromedin U

✍ Scribed by Sato, Shingo; Hanada, Reiko; Kimura, Ayako; Abe, Tomomi; Matsumoto, Takahiro; Iwasaki, Makiko; Inose, Hiroyuki; Ida, Takanori; Mieda, Michihiro; Takeuchi, Yasuhiro

Book ID: 109933048
Publisher: Nature Publishing Group
Year: 2007
Tongue: English
Weight: 618 KB
Volume: 13
Category: Article
ISSN: 1078-8956
DOI: 10.1038/nm1640

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## Abstract Tumor suppressor p53 is a transcription regulator that displays anti‐proliferation activities once activated by stress, in particular genotoxic stress. Recent mouse genetic studies revealed a critical role for p53 in bone remodeling, supported by both loss‐of‐function and gain‐of functi