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Central administration of a CRF antagonist blocks the development of stress-induced behavioral sensitization

✍ Scribed by Belinda J. Cole; Martine Cador; Luis Stinus; Jean Rivier; Wylie Vale; George F. Koob; Michel Le Moal


Book ID
115800604
Publisher
Elsevier Science
Year
1990
Tongue
English
Weight
370 KB
Volume
512
Category
Article
ISSN
0006-8993

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Morphine (3.0 mg/kg, SC) stimulates locomotor activity in rats, and this effect sensitizes with repeated intermittent treatment. We examined the ability of the AMPA antagonist LY293558, administered systemically over a range of doses (0.1-3.0 mg/kg), to alter morphine sensitization. Pretreatment wit