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Central action of phentolamine administered intraventricularly in the rat

✍ Scribed by Z. Kleinrok; I. Żebrowska-Łupina

Publisher
Springer
Year
1971
Tongue
English
Weight
364 KB
Volume
20
Category
Article
ISSN
0033-3158

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✦ Synopsis

Phentolamine injected intraventricularly in unanaesthetized rats decreased their locomotor activity and antagonized the excitatory effect of intraventricularly injected noradrenaline, or amphetamine injected s.c. Phentolamine did not influence the level of noradrenaline and 5-hydroxytryptamine in the rat brain. The mechanism of observed action of phentolamine is discussed.

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