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Cellular uptake, subcellular distribution and toxicity of arsenic compounds in methylating and non-methylating cells

โœ Scribed by E. Dopp; U. von Recklinghausen; R. Diaz-Bone; A.V. Hirner; A.W. Rettenmeier


Book ID
116451160
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
895 KB
Volume
110
Category
Article
ISSN
0013-9351

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Biomethylation is considered a major detoxification pathway for inorganic arsenicals (iAs). According to the postulated metabolic scheme, the methylation of iAs yields methylated metabolites in which arsenic is present in both pentavalent and trivalent forms. Pentavalent mono- and dimethylated arsen