Cellular Transformation by the HTLV-I Tax Protein, a Jack-of-All-Trades
โ Scribed by Gatza, Michael L; Watt, Julie C; Marriott, Susan J
- Book ID
- 110067650
- Publisher
- Nature Publishing Group
- Year
- 2003
- Tongue
- English
- Weight
- 182 KB
- Volume
- 22
- Category
- Article
- ISSN
- 0950-9232
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## Abstract The high mobility group protein B1 (HMGB1) is a highly abundant protein with roles in several cellular processes, including chromatin structure and transcriptional regulation, as well as an extracellular role in inflammation. HMGB1's most thoroughly defined function is as a protein capa
It was shown previously that mouse bone marrow cells transformed by simian virus 40 (SV40) show a reversible cell density-dependent phenotypic transition between the nonmacrophage (rapidly growing) and the macrophage (stationary) states; cells in low-density cultures are in the growing phase, expres