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Cellular theories of aging as related to the liver

✍ Scribed by J. Fred Dice Jr.

Publisher
John Wiley and Sons
Year
1985
Tongue
English
Weight
728 KB
Volume
5
Category
Article
ISSN
0270-9139

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✦ Synopsis

The age-associated decline in function of several organs, including the liver, may be caused by mechanisms operating on the cellular level. Fibroblasts and several other cell types derived from normal individuals have limited lifespans in culture, and several abnormalities described for senescent cultured fibroblasts also apply to hepatocytes and other cell types obtained from aged organisms.

Cellular theories of aging can be divided into two broad and overlapping categories: (a) those that view cell death as an actively programmed developmental process, and (b) those that consider cellular aging to result from a passive accumulation of errors in macromolecules. These theories are not necessarily mutually exclusive, and many of the phenotypic changes in senescent hepatocytes, fibroblasts and other cells are compatible with several different theories. The challenge for the future is to distinguish primary causes from secondary consequences of cellular aging so that rational attempts to intervene in the aging process are possible.

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## HEPATOLOGY Copyright (C 19% by the American Asscx.iati(in for the Studv ol Imer Diseases