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Cellular signaling and biological functions of R-spondins

✍ Scribed by Jeong Kyo Yoon; Jin-Seon Lee

Book ID
113528594
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
606 KB
Volume
24
Category
Article
ISSN
0898-6568

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Objective. Clinical and in vitro studies suggest that altered osteogenesis or bone remodeling is involved in the progression and/or onset of osteoarthritis (OA). Wnt signaling plays a key role in osteogenesis via the canonical Wnt/␀-catenin signaling pathway. Two of the R-spondins, Rspo-1 and Rspo-2