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Cellular roles of neuronal calcium sensor-1 and calcium/calmodulin-dependent kinases in fungi

✍ Scribed by Dr. Ranjan Tamuli; Ravi Kumar; Rekha Deka

Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
846 KB
Volume
51
Category
Article
ISSN
0233-111X

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✦ Synopsis

Abstract

The neuronal calcium sensor‐1 (NCS‐1) possesses a consensus signal for N‐terminal myristoylation and four EF‐hand Ca^2+^‐binding sites, and mediates the effects of cytosolic Ca^2+^. Minute changes in free intracellular Ca^2+^ are quickly transformed into changes in the activity of several kinases including calcium/calmodulin‐dependent protein kinases (Ca^2+^/CaMKs) that are involved in regulating many eukaryotic cell functions. However, our current knowledge of NCS‐1 and Ca^2+^/CaMKs comes mostly from studies of the mammalian enzymes. Thus far very few fungal homologues of NCS‐1 and Ca^2+^/CaMKs have been characterized and little is known about their cellular roles. In this minireview, we describe the known sequences, interactions with target proteins and cellular roles of NCS‐1 and Ca^2+^/CaMKs in fungi. (© 2011 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)

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