✦ LIBER ✦

Cellular reactions against Burkitt lymphoma cells. III. Effector cell activity of leukocytes stimulated in vitro with autochthonous cultured lymphoma cells

✍ Scribed by Sidney H. Golub; Erik A. J. Svedmyr; John F. Hewetson; George Klein; Surjit Singh

Publisher: John Wiley and Sons
Year: 1972
Tongue: French
Weight: 580 KB
Volume: 10
Category: Article
ISSN: 0020-7136
DOI: 10.1002/ijc.2910100121

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✦ Synopsis

Abstract

Peripheral blood leukocytes from four patients with Burkitt's lymphoma (BL) were studied for immunological reactions with lymphoblastoid culture line cells. In all four cases peripheral blood leukocytes could reproducibly be stimulated with autochthonous cultured cells derived from tumor biopsies. Stimulation could be accomplished despite the inability of the unstimulated lymphocytes to mediate a cytotoxic response. Leukocytes which have been stimulated with the autochthonous cells displayed strong colony inhibiting activity against the autochthonous BL‐derived target cell, but considerably less activity against two non‐BL‐derived target cells. Autochthonous fibroblasts were ineffective as stimulator cells.

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Cellular reactions against Burkitt lymph

Cellular reactions against Burkitt lymphoma cells. II. Effector cells obtained by allogeneic stimulation in mixed leukocyte cultures

✍ Sidney H. Golub; John F. Hewetson; Erik A. J. Svedmyr; Surjit Singh 📂 Article 📅 1972 🏛 John Wiley and Sons 🌐 French ⚖ 487 KB

## Abstract A new colony inhibition test has been employed to detect effector cell activity of normal human leukocytes after stimulation with allogeneic cells. The responding cells in one‐way mixed leukocyte culture show strong activity in this assay, and effector cell activity is at least in part