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Cellular metabolism of 1-β-d-arabinofuranosyl-5-azacytosine and incorporation into DNA and RNA of human lymphoid CEM/0 and CEM/dCk(−) cells

✍ Scribed by Vassilios I. Avramis; William C. Powell; Robert A. Mecum

Book ID: 104890933
Publisher: Springer
Year: 1989
Tongue: English
Weight: 631 KB
Volume: 25
Category: Article
ISSN: 0344-5704
DOI: 10.1007/bf00694333

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## Abstract The cytotoxic effect of 1‐β‐D‐arabinofuranosyl cytosine (araC) depends on the intracellular phosphorylation into its active compound araCTP, on the degree of degradation of araCTP and on the incorporation of araCTP into DNA. Deoxycytidine triphosphate (dCTP) inhibits the phosphorylation