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Cellular Mechanisms Underlying the Antidepressant Effects of Ketamine: Role of α-Amino-3-Hydroxy-5-Methylisoxazole-4-Propionic Acid Receptors

✍ Scribed by Sungho Maeng; Carlos A. Zarate Jr; Jing Du; Robert J. Schloesser; Joseph McCammon; Guang Chen; Husseini K. Manji


Book ID
119197655
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
226 KB
Volume
63
Category
Article
ISSN
0006-3223

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α-Amino-3-hydroxy-5-methylisoxazole-4-pr
✍ J.H. Fowler; J.M. Edgar; A. Pringle; M. McLaughlin; J. McCulloch; I.R. Griffiths 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 378 KB

## Abstract In vivo and in vitro studies have shown that α‐amino‐3‐hydroxy‐5‐methylisoxazole‐4‐propionic acid (AMPA)‐receptor‐mediated excitotoxicity causes cytoskeletal damage to axons. AMPA/kainate receptors are present on oligodendrocytes and myelin, but currently there is no evidence to suggest