Three mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene were discovered in a pancreas-insufficient patient with cystic fibrosis (CF) who displayed an uncommon combination of almost normal chloride concentration in sweat tests and typical symptoms of gastrointestinal an
Cellular localization of the cystic fibrosis transmembrane conductance regulator in mouse intestinal tract
β Scribed by Nadia Ameen; John Alexis; Pedro Salas
- Publisher
- Springer
- Year
- 2000
- Tongue
- English
- Weight
- 105 KB
- Volume
- 114
- Category
- Article
- ISSN
- 1432-119X
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Cystic fibrosis transmembrane conductance regulator (CFTR) mRNA transcripts isolated from both expressing and "non-expressing" cell types of normal individuals exhibit differential splicing to a variable extent in a region encoding the putative nucleotide binding fold of the CFTR polypeptide. Sequen
## Communicated by Lap-Chee Tsui German cystic fibrosis (CF) chromosomes were screened for molecular lesions in exon 20 of the cystic fibrosis transmembrane conductance regulator (CFTR) gene by chemical cleavage of mismatch. An 3884G-to-A transition was detected in two patients which leads to an e