## Abstract Rab3a, a small GTPase important for exocytosis, is uniquely upβregulated as oligodendrocytes enter terminal differentiation and initiate myelin biosynthesis. In this study, we analyze the role of this protein in oligodendrocyte morphological differentiation by using Rab3a overexpression
Cellular interactions and oligodendrocyte differentiation in vitro
β Scribed by G. Levi; C. Agresti
- Publisher
- Springer
- Year
- 1991
- Tongue
- English
- Weight
- 396 KB
- Volume
- 5
- Category
- Article
- ISSN
- 0920-9069
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
The development of oligodendrocytes in the chicken optic tectum (OT) was studied in vivo and in vitro by analyzing expression of myelin-associated glycoprotein (MAG) with a monoclonal antibody. MAG(+) cells first appeared in the anterior OT on embryonic day (E) 12, were present throughout the anteri
## Abstract Following experimental demyelination in rodents, oligodendrocyte precursor cells (OPCs) proliferate and differentiate into myelinβproducing oligodendrocytes which effect robust remyelination. In contrast, remyelination in multiple sclerosis, the major human demyelinating disease, is gen
We have generated stage-specific oligodendrocytes, which are identified as immature oligodendrocytes by the expression of specific markers. These cells were generated by using 3 types of intrinsic and extrinsic factors for influencing the characteristics of oligodendrocyte-lineage cells. The factors
## Abstract Transferrin (Tf), the iron transport glycoprotein found in biological fluids of vertebrates, is synthesized mainly by hepatocytes. Tf is also synthesized by oligodendrocytes (Ol), and several lines of evidence indicate that brain Tf could be involved in myelinogenesis. Because Tf is pos