Cellular immunity to human urinary bladder carcinoma. II. Effect of surgery and preoperative irradiation
✍ Scribed by C. O'Toole; P. Perlmann; B. Unsgaard; L. E. Almgård; B. Johansson; G. Moberger; F. Edsmyr
- Publisher
- John Wiley and Sons
- Year
- 1972
- Tongue
- French
- Weight
- 472 KB
- Volume
- 10
- Category
- Article
- ISSN
- 0020-7136
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✦ Synopsis
Abstract
A group of patients with carcinoma of the urinary bladder treated by local resection or total cystectomy were studied in regard to tumour specific cytotoxicity of their lymphocytes. Only one in a group of five, treated by transurethral resection, had cytotoxic lymphocytes when tested within 1 yr after surgery. This patient alone in the group had a residual growing tumour at the time of testing. Total cystectomy in five patients led to complete disappearance of cytotoxicity in two and almost complete disappearance in a third. One patient was negative both before and after surgery. These four patients were free of macroscopic tumour when tested 4–8 weeks after surgery. The patient whose lymphocytes were strongly cytotoxic after surgery had suspected residual tumour foci in the urethra at 5 weeks after operation. Preoperative irradiation of the tumour produced a systemic response which was maintained after total cystectomy in three of four patients for at least 3–7 months. The patient who was negative when tested after cystectomy was in poor general health. All four patients were clinically tumour‐free at the time of post‐operative lymphocyte sampling. These results favour the interpretation that the maintenance of a cellular response to this tumour is dependent on the presence of tumour material in the body. Stimulation of the immune response measured may be produced or maintained by localized primary tumours or by material released systemically as a result of tumour necrosis.