Cellular immunity and its serum-mediated inhibition in shope-virus-induced rabbit papillomas
✍ Scribed by Ingegerd Hellström; Charles A. Evans; Karl Erik Hellström
- Book ID
- 102866546
- Publisher
- John Wiley and Sons
- Year
- 1969
- Tongue
- French
- Weight
- 563 KB
- Volume
- 4
- Category
- Article
- ISSN
- 0020-7136
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✦ Synopsis
A colony-inhibition technique was used to demonstrate lymph-node-cell ( L N C ) mediated immune reactions against tumor-specific transplantation antigens of Shopevirus-induced papilloma and carcinoma cells. Lymph-node cells from rabbits in which
Shope papillomas had regressed spontaneously, as well as L N C ,from rabbits with persistent Shope papillomas, reduced the plating efficiency of Shope-virus-induced papilloma and carcinoma cells but did not aflect normal skin fibroblasts from the same rabbits as the tumor cells.
Serum from rabbits with persistent Shope papillornus or Shope carcinomas abro-gGted the inhibitory effect of regressor LNC on Shope turnor cells, while serum from regressor rabbits had no such efect. It is postulated that sera from '' persistor" and
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