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Cellular functions of the dual-targeted catalytic subunit of telomerase, telomerase reverse transcriptase — Potential role in senescence and aging

✍ Scribed by Ale-Agha, Niloofar; Dyballa-Rukes, Nadine; Jakob, Sascha; Altschmied, Joachim; Haendeler, Judith

Book ID
122282861
Publisher
Elsevier Science
Year
2014
Tongue
English
Weight
407 KB
Volume
56
Category
Article
ISSN
0531-5565

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## Abstract ## BACKGROUND The stabilization of telomere lengths by telomerase activation is an important step in carcinogenesis and cell immortalization. Human telomerase reverse transcriptase (hTERT) is the catalytic subunit of this enzyme. The objective of this study was to evaluate the use of r