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Cellular environments and apoptosis: tissue microenvironments control activated T-cell death

✍ Scribed by Arne N. Akbar; Mike Salmon

Publisher: Elsevier Science
Year: 1997
Tongue: English
Weight: 545 KB
Volume: 18
Category: Article
ISSN: 0167-5699
DOI: 10.1016/s0167-5699(97)01003-7

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✦ Synopsis

I Cytoktne deprtvatton 'Starvation' (wolves W-2 and Bcl-x,) Memory T cell FEBRUARY I997 IMMUNOLOGY TODAY Activated T cell Cytokme-mediated reso"e . No rescue High Bcl-2 High Bcl-x, Huh GSH Low 3~1-2 High B&x, High GSH Ceils cycling Low Bcl-2 Low B&x, Low GSH Cells quiescent ytokine-deprivtd T cells after fibroblast co-cultore, the level of B&x, emained high':. This suggests that fibroblasts may prevent apop-Jsis of cytokine-deprived T cells by the selective induction of Lkl-x,

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