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Cellular energy sensing and signaling by AMP-activated protein kinase

✍ Scribed by William W. Winder; David M. Thomson

Publisher
Springer-Verlag
Year
2007
Tongue
English
Weight
357 KB
Volume
47
Category
Article
ISSN
1085-9195

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## Abstract The AMP‐activated protein kinase cascade is a sensor of cellular energy charge, and its existence provides strong support for the energy charge hypothesis first proposed by Daniel Atkinson in the 1960s. The system is activated in an ultrasensitive manner by cellular stresses that deplet